• Take SEROQUEL XR exactly as your health care
provider tells you to take it. Do not change the dose
yourself.
• Take SEROQUEL XR by mouth, with a light meal
or without food.
• SEROQUEL XR should be swallowed whole and
not split, chewed or crushed.
• If you feel you need to stop SEROQUEL XR, talk with
your health care provider first.
If you suddenly stop taking SEROQUEL XR, you may
experience side effects such as trouble sleeping or
trouble staying asleep (insomnia), nausea, and vomiting.
• If you miss a dose, take it as soon as you remember.
If it is close to the next dose, skip the missed dose.
Just take the next dose at your regular time. Do not
take 2 doses at the same time unless your health care
provider tells you to. If you are not sure about your
dosing, call your health care provider.
• If you take too much SEROQUEL XR, call your health
care provider or poison control center at
1-800-222-1222 right away or go to the nearest
hospital emergency room.
What should I avoid while taking
SEROQUEL XR?
Do not drive, operate machinery, or do other dangerous
activities until you know how SEROQUEL XR affects you.
SEROQUEL XR may make you drowsy.
• Avoid getting overheated or dehydrated.
– Do not over-exercise.
– In hot weather, stay inside in a cool place if
possible.
– Stay out of the sun. Do not wear too much or
heavy clothing.
– Drink plenty of water.
• Do not drink alcohol while taking SEROQUEL XR.
It may make some side effects of SEROQUEL XR
worse.
What are possible side effects
of SEROQUEL XR?
Also see “What is the most important information
I should know about SEROQUEL XR?” at the beginning
of this document.
Serious side effects have been reported with
SEROQUEL XR including:
• Neuroleptic malignant syndrome (NMS): Tell your
health care provider right away if you have some or
all of the following symptoms: high fever, stiff
muscles, confusion, sweating, changes in pulse,
heart rate, and blood pressure. These may be
symptoms of a rare and serious condition that can
lead to death. Stop SEROQUEL XR and call your
health care provider right away
• High blood sugar (hyperglycemia): Increases
in blood sugar can happen in some people who
take SEROQUEL XR. Extremely high blood sugar
can lead to coma or death. If you have diabetes or risk
factors for diabetes (such as being overweight or a
family history of diabetes) your health care provider
should check your blood sugar before you start
SEROQUEL XR and during therapy
Call your health care provider if you have any of
these symptoms of high blood sugar while taking
SEROQUEL XR
• High cholesterol and triglyceride levels in the blood
(fat in the blood): Increases in total cholesterol,
triglycerides and LDL (bad) cholesterol and decreases
in HDL (good) cholesterol have been reported in
clinical trials with SEROQUEL XR. You may not have
any symptoms, so your health care provider should
do blood tests to check your cholesterol and tri-
glyceride levels before you start taking SEROQUEL XR
and during therapy
• Increase in weight (weight gain): Weight gain has
been seen in patients who take SEROQUEL XR so
you and your health care provider should check your
weight regularly
• Tardive dyskinesia: Tell your health care provider
about any movements you cannot control in your
face, tongue, or other body parts. These may be signs
of a serious condition. Tardive dyskinesia may not go
away, even if you stop taking SEROQUEL XR. Tardive
dyskinesia may also start after you stop taking
SEROQUEL XR
• Orthostatic hypotension (decreased blood pressure):
lightheadedness or fainting caused by a sudden
change in heart rate and blood pressure when rising
too quickly from a sitting or lying position
• Increases in blood pressure: reported in children and
teenagers. Your health care provider should check
blood pressure in children and adolescents before
starting SEROQUEL XR and during therapy.
SEROQUEL XR is not approved for patients under
18 years of age
• Low white blood cell count
• Cataracts
• Seizures
• Abnormal thyroid tests: Your health care provider may
do blood tests to check your thyroid hormone level
• Increases in prolactin levels: Your health care
provider may do blood tests to check your prolactin
levels
• Increases in liver enzymes: Your health care
provider may do blood tests to check your liver
enzyme levels
• Long lasting and painful erection
• Difficulty swallowing
Common possible side effects with SEROQUEL XR
include:
SEROQUEL XR is a registered trademark of the AstraZeneca group of
companies.
© 2010 AstraZeneca
AstraZeneca Pharmaceuticals LP
Wilmington, DE 19850
298371 6/10
For more information about SEROQUEL XR,
visit
www.SEROQUELXR.com or call 1-800-236-9933.
